The therapeutic potential of cannabinoids for integumentary wound management

• Published in: Experimental dermatology Vol. 30; no. 2; pp. 201 - 211
• Main Authors: Weigelt, Maximillian A., Sivamani, Raja, Lev‐Tov, Hadar
• Format: Journal Article
• Language: English
• Published: Denmark Wiley Subscription Services, Inc 01.02.2021
• Subjects: Acute Disease; alternative medicine; Animals; Cannabinoids; Cannabinoids - metabolism; Cannabinoids - pharmacology; Cannabinoids - therapeutic use; Cannabis; Chronic Disease; endocannabinoid; Endocannabinoid system; Humans; inflammation; Inflammation - drug therapy; keratinocytes; Keratinocytes - drug effects; Keratinocytes - physiology; microenvironment; Nitric Oxide - metabolism; Phenotype; Skin - injuries; Skin - metabolism; Skin diseases; Stem Cells - drug effects; Wound healing; Wound Healing - drug effects; Wounds and Injuries - therapy; microenvironment; endocannabinoid; alternative medicine; keratinocytes; inflammation
• ISSN: 0906-6705; 1600-0625
• DOI: 10.1111/exd.14241

The increasing legalization of Cannabis for recreational and medicinal purposes in the United States has spurred renewed interest in the therapeutic potential of cannabinoids (CBs) for human disease. The skin has its own endocannabinoid system (eCS) which is a key regulator of various homeostatic processes, including those necessary for normal physiologic wound healing. Data on the use of CBs for wound healing are scarce. Compelling pre‐clinical evidence supporting the therapeutic potential of CBs to improve wound healing by modulating key molecular pathways is herein reviewed. These findings merit further exploration in basic science, translational and clinical studies.