Pure FSH for ovulation induction in patients with polycystic ovary syndrome and resistant to clomiphene citrate therapy

Twenty-nine infertile women with polycystic ovary disease which was resistant to therapy with clomiphene citrate underwent a combined treatment for follicle recruitment consisting of pure FSH during the first days of the cycle and HMG during the last days of the follicular phase. Sixty cycles were s...

Full description

Saved in:
Bibliographic Details
Published inHuman reproduction (Oxford) Vol. 6; no. 2; p. 218
Main Authors Neyro, J L, Barrenetxea, G, Montoya, F, Rodriguez-Escudero, F J
Format Journal Article
LanguageEnglish
Published England 01.02.1991
Subjects
Adult
Clomiphene - therapeutic use
Drug Resistance - physiology
Estradiol - blood
Female
Follicle Stimulating Hormone - therapeutic use
Hormones - blood
Humans
Infertility, Female - drug therapy
Infertility, Female - etiology
Ovulation Induction - methods
Polycystic Ovary Syndrome - complications
Polycystic Ovary Syndrome - physiopathology
Pregnancy
Pregnancy Outcome
Online AccessGet more information

Cover

More Information
Summary:Twenty-nine infertile women with polycystic ovary disease which was resistant to therapy with clomiphene citrate underwent a combined treatment for follicle recruitment consisting of pure FSH during the first days of the cycle and HMG during the last days of the follicular phase. Sixty cycles were stimulated of which 83% were ovulatory. Eighteen pregnancies were achieved (36% of cycles, 62% of patients). The multiple pregnancy rate was 39%. Twelve cycles (20%) showed the ovarian hyperstimulation syndrome (OHS) although seven of these resulted in full term deliveries. There were no miscarriages among the patients studied.
ISSN:0268-1161
DOI:10.1093/oxfordjournals.humrep.a137309