Peptide Materials for Smart Therapeutic Applications

• Published in: Macromolecular research Vol. 29; no. 1; pp. 2 - 14
• Main Authors: Lee, Jeonghun, Kim, Chulhee
• Format: Journal Article
• Language: English
• Published: Seoul The Polymer Society of Korea 01.01.2021; Springer Nature B.V; 한국고분자학회
• Subjects: Assemblies; Characterization and Evaluation of Materials; Chemistry; Chemistry and Materials Science; Complex Fluids and Microfluidics; Nanochemistry; Nanotechnology; Peptides; Physical Chemistry; Polymer Sciences; Review; Selective binding; Self-assembly; Soft and Granular Matter; 고분자공학; selective binding; peptides; therapeutic materials; stimuli-responsiveness; self-assembled structures
• ISSN: 1598-5032; 2092-7673
• DOI: 10.1007/s13233-021-9011-x

Myriad peptides have been reported for utilization as key motives in design of smart therapeutic materials due to their capabilities for selective binding, self-assembly, and bioresponsiveness. In this review, we describe various therapeutic applications of peptides, their derivatives, and their assemblies by employing the bioresponsive characteristics. Peptide materials have been developed for specific targeting or deep tissue penetration. Amphiphilic peptides and their self-assembled materials also have been adopted for the development of therapeutic materials. Furthermore, triggered structural transformation of the self-assemblies of peptides in response to various stimuli in biological environments facilitates diverse therapeutic applications of peptide materials.