Association between AKT1 gene polymorphisms and depressive symptoms in the Chinese Han population with major depressive disorder

For this study, 461 Chinese Han patients with depressive disorder were recruited. The AKT1 genotype and allele distribution were determined by PCR amplification and direct sequencing. UNPHASED software was used to analyze associations between the 17-item Hamilton Depression Rating Scale, total score...

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Published inNeural regeneration research Vol. 7; no. 3; pp. 235 - 239
Main Authors Yang, Chunxia, Sun, Ning, Ren, Yan, Sun, Yan, Xu, Yong, Li, Aiping, Wu, Kewen, Zhang, Kerang
Format Journal Article
LanguageEnglish
Published India First Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China%Department of Psychiatry, Three Hospital of Shanxi Medical University, Taiyuan 030053, Shanxi Province, China%Rongjun Kangning Psychiatric Hospital of Shanxi Province,Taigu 030800 , Shanxi Province, China 25.01.2012
Medknow Publications & Media Pvt Ltd
Subjects
Clinical Practice
PCR扩增
中国汉族人群
协会
基因分布
基因多态性
抑郁症
症状
等位基因
symptoms
AKT1
polymorphism
neural regeneration
major depression
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Summary:For this study, 461 Chinese Han patients with depressive disorder were recruited. The AKT1 genotype and allele distribution were determined by PCR amplification and direct sequencing. UNPHASED software was used to analyze associations between the 17-item Hamilton Depression Rating Scale, total score, four factors and the AKT1 rs2494746 and rs3001371 polymorphisms. The results indicate that there is a significant association between suicidal ideation and anxiety symptoms in depressed patients and the rs2494746 polymorphism. The other AKT1 polymorphism, rs3001371, was significantly associated with work and activities. Patients with the rs3001371-A allele had a significantly more severe illness compared to patients with the rs3001371-G allele. Thus, AKT1 polymorphisms appear to be associated with depression severity, anxiety symptoms, work and activities, and suicide attempts in patients with depressive disorder.
Bibliography:For this study, 461 Chinese Han patients with depressive disorder were recruited. The AKT1 genotype and allele distribution were determined by PCR amplification and direct sequencing. UNPHASED software was used to analyze associations between the 17-item Hamilton Depression Rating Scale, total score, four factors and the AKT1 rs2494746 and rs3001371 polymorphisms. The results indicate that there is a significant association between suicidal ideation and anxiety symptoms in depressed patients and the rs2494746 polymorphism. The other AKT1 polymorphism, rs3001371, was significantly associated with work and activities. Patients with the rs3001371-A allele had a significantly more severe illness compared to patients with the rs3001371-G allele. Thus, AKT1 polymorphisms appear to be associated with depression severity, anxiety symptoms, work and activities, and suicide attempts in patients with depressive disorder.
AKT1; major depression; symptoms; polymorphism; neural regeneration
11-5422/R
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Chunxia Yang, Master, First Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China
Author contributions: Dr. Kerang Zhang designed the study and wrote the protocol and obtained funding, implemented all experimental procedures, contributed to the conceptualization of the study and reviewed several manuscript drafts. Chunxia Yang, Ning Sun and Aiping Li were responsible for all aspects of patient recruitment and clinical diagnostic assessment. Yan Ren, Kewen Wu and Yan Sun contributed to data collection. Yong Xu and Chunxia Yang undertook the statistical analysis and prepared the first draft. All authors contributed to and approved the final manuscript.
ISSN:1673-5374
1876-7958
DOI:10.3969/j.issn.1673-5374.2012.03.014