Mechanisms of resistance to insecticides targeting RDL GABA receptors in planthoppers
•A2′S/G mutations in RDL GABA receptor confer cyclodiene resistance in various pests.•A2′S/G mutations confer low level of cross resistance to fipronil.•A2′N mutation in RDL GABA receptor confers fipronil resistance in planthoppers.•PCR-RFLP assays were developed for detecting fipronil-resistant pla...
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Published in | Neurotoxicology (Park Forest South) Vol. 60; pp. 293 - 298 |
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Main Author | |
Format | Journal Article |
Language | English |
Published |
Netherlands
Elsevier B.V
01.05.2017
Elsevier BV |
Subjects | |
Online Access | Get full text |
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Summary: | •A2′S/G mutations in RDL GABA receptor confer cyclodiene resistance in various pests.•A2′S/G mutations confer low level of cross resistance to fipronil.•A2′N mutation in RDL GABA receptor confers fipronil resistance in planthoppers.•PCR-RFLP assays were developed for detecting fipronil-resistant planthoppers.•There is a need to develop novel insecticides effective against A2′ mutations.
Lindane and cyclodienes, such as dieldrin and α-endosulfan, represent the first generation of noncompetitive antagonists (NCAs) against the insect RDL GABA receptor. It has been reported that A2′S and A2′G mutations in the membrane-spanning region M2 of the RDL GABA receptor confer resistance to lindane and cyclodienes. Fipronil is a second-generation NCA, but A2′S and A2′G mutations provide a low level of cross-resistance to fipronil. Moreover, a novel A2′N mutation that confers fipronil resistance was found in M2 of the RDL GABA receptors from fipronil-resistant planthoppers in the heterozygous state. Thus, problems are being caused by a worldwide appearance of cyclodiene-resistant pests. And attention must be paid to development of fipronil-resistant planthoppers, such as Sogatella furcifera and Laodelphax striatellus in Japan. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0161-813X 1872-9711 |
DOI: | 10.1016/j.neuro.2016.03.009 |