Ghrelin and Obesity: Identifying Gaps and Dispelling Myths. A Reappraisal

The etiology of obesity is complex. Environmental and genetic causes have been implicated in the development of this disease. Ghrelin is a hormone known to stimulate appetite. There are numerous possible actions through which ghrelin exerts its effect in the body: a) Overproduction of ghrelin, b) re...

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Published inIn vivo (Athens) Vol. 31; no. 6; pp. 1047 - 1050
Main Authors Makris, Marinos C, Alexandrou, Andreas, Papatsoutsos, Efstathios G, Malietzis, George, Tsilimigras, Diamantis I, Guerron, Alfredo D, Moris, Demetrios
Format Journal Article
LanguageEnglish
Published Greece International Institute of Anticancer Research 01.11.2017
Subjects
Review
bariatric surgery
Ghrelin
review
appetite
diet
hormone levels
obesity
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Summary:The etiology of obesity is complex. Environmental and genetic causes have been implicated in the development of this disease. Ghrelin is a hormone known to stimulate appetite. There are numerous possible actions through which ghrelin exerts its effect in the body: a) Overproduction of ghrelin, b) reduced ghrelin following meals, and c) increased receptor sensitivity to ghrelin action. Sleeve gastrectomy, a bariatric procedure, leads to reduction of ghrelin levels and subsequently to weight loss. However, there are many limitations to measurement of the fasting plasma level of the active form of ghrelin. The establishment of the exact correlation between ghrelin, appetite and obesity could be vital for the fight against obesity.
Bibliography:ObjectType-Article-2
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ISSN:1791-7549
0258-851X
1791-7549
DOI:10.21873/invivo.11168