Rabies pre-exposure prophylaxis: A 10-year experience of vaccination in international travelers

• Published in: Travel medicine and infectious disease Vol. 28; pp. 102 - 103
• Main Authors: Tan, Eugene M., Agarwal, Sumit K., Marcelin, Jasmine R., Virk, Abinash
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.03.2019; Elsevier Limited
• Subjects: Antibodies, Viral - blood; Centers for Disease Control and Prevention (U.S.); Conflicts; Conflicts of interest; Disease control; Disease prophylaxis; Humans; Immunization; Immunoglobulins; Infectious diseases; Laboratories; Pre-exposure prophylaxis; Pre-Exposure Prophylaxis - legislation & jurisprudence; Pre-Exposure Prophylaxis - statistics & numerical data; Prophylaxis; Protection; Rabies; Rabies - prevention & control; Rabies Vaccines; Travel; Travel - statistics & numerical data; Travel medicine; United States; Vaccination; Vaccines; United States; Kansas; Asia; United States > US; Africa; Travel; Immunization; CDC; Rabies; Vaccination; PrEP; Pre-exposure prophylaxis; WHO
• ISSN: 1477-8939; 1873-0442
• DOI: 10.1016/j.tmaid.2018.07.003

Rabies pre-exposure prophylaxis (PrEP) includes three intramuscular (IM) vaccine doses, eliciting production of rabies virus neutralizing antibody (RVNA), which is a surrogate marker for protection. The Centers for Disease Control and Prevention (CDC) recommend periodic boosters based on continual risk such as work in rabies research or vaccine production facilities and evidence of waning antibody response (titer < 0.5 IU/ml). [...]given the uncertainty of rabies protection, serologic testing and/or booster vaccination may need to be considered for repeat travelers to areas with risk of rabies.Conflicts of interest None.Author contributions EMT performed data analysis, literature search, table preparation, and manuscript writing.