Bcl10 Is a Positive Regulator of Antigen Receptor–Induced Activation of NF-κ B and Neural Tube Closure
Bcl10, a CARD-containing protein identified from the t(1;14)(p22;q32) breakpoint in MALT lymphomas, has been shown to induce apoptosis and activate NF- κ B in vitro. We show that one-third of bcl10 −/− embryos developed exencephaly, leading to embryonic lethality. Surprisingly, bcl10 −/− cells retai...
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Published in | Cell Vol. 104; no. 1; pp. 33 - 42 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Elsevier Inc
12.01.2001
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Subjects | |
Online Access | Get full text |
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Summary: | Bcl10, a CARD-containing protein identified from the t(1;14)(p22;q32) breakpoint in MALT lymphomas, has been shown to induce apoptosis and activate NF-
κ B in vitro. We show that one-third of bcl10
−/− embryos developed exencephaly, leading to embryonic lethality. Surprisingly, bcl10
−/− cells retained susceptibility to various apoptotic stimuli in vivo and in vitro. However, surviving bcl10
−/− mice were severely immunodeficient and bcl10
−/− lymphocytes are defective in antigen receptor or PMA/Ionomycin-induced activation. Early tyrosine phosphorylation, MAPK and AP-1 activation, and Ca
2+ signaling were normal in mutant lymphocytes, but antigen receptor–induced NF-
κ B activation was absent. Thus, Bcl10 functions as a positive regulator of lymphocyte proliferation that specifically connects antigen receptor signaling in B and T cells to NF-
κ B activation. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
ISSN: | 0092-8674 1097-4172 |
DOI: | 10.1016/S0092-8674(01)00189-1 |