Peptides conjugation on biomaterials: chemical conjugation approaches and their promoted multifunction for biomedical applications

• Published in: Biotechnology and bioprocess engineering Vol. 29; no. 3; pp. 427 - 439
• Main Authors: Kim, Jiwon, Choi, Yonghyun, Park, Jongjun, Lee, Hee-Young, Choi, Jonghoon
• Format: Journal Article
• Language: English
• Published: Seoul The Korean Society for Biotechnology and Bioengineering 01.06.2024; Springer Nature B.V; 한국생물공학회
• Subjects: Amino acids; biocompatible materials; Biodegradability; Biodegradation; Biomaterials; Biomedical materials; Biomolecules; Biotechnology; Chemical modification; Chemistry; Chemistry and Materials Science; Conjugation; cost effectiveness; Engineering; Industrial and Production Engineering; Peptides; Polypeptides; Proteins; Review Paper; Signal transduction; Therapeutic applications; therapeutics; 생물공학; Immobilization; Chemical conjugation; Peptide; Biomaterials
• ISSN: 1226-8372; 1976-3816
• DOI: 10.1007/s12257-024-00095-5

Researchers have made significant efforts to attach peptides to various biomaterials, resulting in diverse functionalities. By harnessing the advantages of peptides, functions such as high specificity, potency, cost-effectiveness, small size for improved tissue penetration and targeted delivery, biodegradability, and novel therapeutic applications can be achieved through their attachment to biomaterials. Of various methods available for modifying biomolecules, chemical techniques are the most established and can effectively immobilize the desired molecule onto a specific surface. This article provides a comprehensive overview of the chemical modification methods used for attaching peptides to various biomaterials in recent studies and showcases some of their latest applications.