Stereoselective Suzuki Coupling Reaction of an α-Bromo-α-fluoro-β-lactam
Abstract A new strategy has been developed for the synthesis of α-aryl-α-fluoro-β-lactams via the Suzuki cross-coupling of α-bromo-α-fluoro-β-lactam with a range of different aryl-(9-BBN) reagents. This method provides facile access to multisubstituted α-fluoro-β-lactams in a diastereoselective mann...
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Published in | Synlett Vol. 26; no. 1; pp. 55 - 58 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Stuttgart · New York
Georg Thieme Verlag
01.01.2015
Thieme Medical Publishers |
Subjects | |
Online Access | Get full text |
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Summary: | Abstract
A new strategy has been developed for the synthesis of α-aryl-α-fluoro-β-lactams via the Suzuki cross-coupling of α-bromo-α-fluoro-β-lactam with a range of different aryl-(9-BBN) reagents. This method provides facile access to multisubstituted α-fluoro-β-lactams in a diastereoselective manner. The synthetic utility of α-bromo-α-fluoro-β-lactam has been demonstrated by the arylation of α-bromo-α-fluoro-β-lactam. |
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ISSN: | 0936-5214 1437-2096 |
DOI: | 10.1055/s-0034-1379637 |