Comparison of three nicotine treatments: initial reactions and preferences with guided use

• Published in: Psychopharmacologia Vol. 182; no. 4; pp. 545 - 550
• Main Authors: Schneider, Nina G., Terrace, Scott, Koury, Margaret A., Patel, Shilpan, Vaghaiwalla, Behram, Pendergrass, Regina, Olmstead, Richard E., Cortner, Chris
• Format: Journal Article
• Language: English
• Published: Berlin Springer 01.11.2005; Springer Nature B.V
• Subjects: Adult; Analysis of Variance; Biological and medical sciences; Chewing Gum; Cross-Over Studies; Dose-Response Relationship, Drug; Drug Administration Routes; Female; Humans; Male; Medical sciences; Middle Aged; Nicotine - administration & dosage; Nicotinic Agonists - administration & dosage; Smoking Cessation - methods; Smoking Cessation - psychology; Time Factors; Tobacco Use Disorder - drug therapy; Tobacco, tobacco smoking; Toxicology; Nicotine inhaler; Replacement therapy; Nicotine replacement treatments; Pharmacotherapy; Intranasal administration; Nicotine nasal spray; Alkaloid; Chemotherapy; Preference; Nose; Dependence; Nicotine gum; Preferences; Comparative study; Tailoring; Nicotine
• ISSN: 0033-3158; 1432-2072
• DOI: 10.1007/s00213-005-0123-3

Misuse or dislike of nicotine replacement treatments (NRTs) undermines their effectiveness. Brief testing among NRTs could allow tailoring by preference to improve outcome. To test initial reactions/preferences to NRTs in a single session crossover design with guided use. Smokers were offered two doses of three NRTs: gum (2 and 4 mg), inhaler, and nasal spray (NNS) in a 5-h test with proper use enforced. Subjects rated each NRT and ranked among NRTs on use variables and preferences. Gum was ranked over inhaler and NNS for "ease of use," "safety" and "prefer in public." Four-milligram gum was rated higher than 2 mg on several variables. With experience, "ease of use" and "liking" improved for gum. Both inhaler and NNS ranked low on considering "use >3 months" vs gum. Dislike of NRT was reflected in refusal of second doses. For those testing all doses (n=9), inhaler ranked last on "relief of withdrawal," "choose under stress," and "choice to help quit." Craving and withdrawal were relieved over time with any NRT use. Sampling of treatments can identify reactions key to initial compliance with these NRTs.