Polymorphisms of the endothelial nitric oxide synthase gene in breast cancer

Nitric oxide (NO) is known to be critically involved in breast carcinogenesis. Genetic polymorphisms of the gene encoding for endothelial nitric oxide synthase (Nos3), the enzyme catalyzing the production of the NO, are known to predispose to malignant disease. Whether these polymorphisms also influ...

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Published inBreast cancer research and treatment Vol. 98; no. 2; pp. 151 - 155
Main Authors HEFLER, Lukas A, GRIMM, Christoph, LANTZSCH, Tilmann, LAMPE, Dieter, KOELBL, Heinz, LEBRECHT, Antje, HEINZE, Georg, TEMPFER, Clemens, REINTHALLER, Alexander, ZEILLINGER, Robert
Format Journal Article
LanguageEnglish
Published Dordrecht Springer 01.07.2006
Springer Nature B.V
Subjects
Biological and medical sciences
Breast cancer
Breast Neoplasms - enzymology
Breast Neoplasms - genetics
Cancer research
Cancer therapies
Case-Control Studies
Exons
Female
Genes
Gynecology. Andrology. Obstetrics
Humans
Mammary gland diseases
Medical research
Medical sciences
Nitric oxide
Nitric Oxide Synthase Type III - genetics
Polymorphism
Polymorphism, Genetic
Risk factors
Tumors
Mammary gland diseases
Genetic variability
Nos3
gene
Genotype
Genetics
Breast cancer
Malignant tumor
Polymorphism
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Summary:Nitric oxide (NO) is known to be critically involved in breast carcinogenesis. Genetic polymorphisms of the gene encoding for endothelial nitric oxide synthase (Nos3), the enzyme catalyzing the production of the NO, are known to predispose to malignant disease. Whether these polymorphisms also influence breast cancer risk is unknown. In the present case-control study, we ascertained 2 polymorphisms of the Nos3 gene cluster (Nos3 exon 7 Glu298Asp and a 27-base pair repeat in intron 4 of Nos3) in 269 Caucasian patients with breast cancer and 244 healthy controls using pyrosequencing and PCR, respectively. Presence of the exon 7 Nos3 polymorphism predisposed women to breast cancer (p=0.03, Odds ratio [95% Confidence Intervals]=1.9 [1.1-3.6]), but was not associated with any clinico-pathological parameters. No significant associations were ascertained with respect to the intron 4 Nos3 polymorphism. In our series, presence of the mutant exon7 Nos3 polymorphism was associated with an increased risk for breast cancer in Caucasian women.
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ISSN:0167-6806
1573-7217
DOI:10.1007/s10549-005-9143-2