Neuropeptide Y activates inwardly-rectifying K(+)-channels in C-cells of amphibian sympathetic ganglia

Neuropeptide Y (NPY) is found in the C-cells yet is absent from the B-cells of amphibian sympathetic ganglia. The effects of this peptide on both cell types were studied using the whole-cell patch-clamp recording technique. Although NPY had little effect on the B-cells, it opened inwardly-rectifying...

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Bibliographic Details
Published inNeuroscience letters Vol. 117; no. 1-2; p. 123
Main Authors Zidichouski, J A, Chen, H, Smith, P A
Format Journal Article
LanguageEnglish
Published Ireland 04.09.1990
Subjects
Animals
Epinephrine - pharmacology
Ganglia, Sympathetic - cytology
Ganglia, Sympathetic - physiology
In Vitro Techniques
Membrane Potentials - drug effects
Muscarine - pharmacology
Neurons - cytology
Neurons - drug effects
Neurons - physiology
Neuropeptide Y - pharmacology
Potassium Channels - drug effects
Potassium Channels - physiology
Rana pipiens
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Summary:Neuropeptide Y (NPY) is found in the C-cells yet is absent from the B-cells of amphibian sympathetic ganglia. The effects of this peptide on both cell types were studied using the whole-cell patch-clamp recording technique. Although NPY had little effect on the B-cells, it opened inwardly-rectifying K(+)-channels in C-cells. This effect of the peptide on C-cell K(+)-channels was similar to that produced by muscarine and adrenaline and may be related to autoreceptor function.
ISSN:0304-3940
DOI:10.1016/0304-3940(90)90130-2