The effect of Helicobacter pylori on insulin resistance

• Published in: Digestive diseases and sciences Vol. 50; no. 11; pp. 2090 - 2093
• Main Authors: AYDEMIR, Selim, BAYRAKTAROGLU, Taner, SERT, Mehmet, SOKMEN, Coskun, ATMACA, Hulusi, MUNGAN, Gorkem, GUN, Banu Dogan, BORAZAN, Ali, USTUNDAG, Yucel
• Format: Journal Article
• Language: English
• Published: Heidelberg Springer 01.11.2005; Springer Nature B.V
• Subjects: Adult; Bacterial diseases; Bacterial diseases of the digestive system and abdomen; Biological and medical sciences; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; Helicobacter Infections - microbiology; Helicobacter Infections - physiopathology; Helicobacter pylori; Helicobacter pylori - physiology; Human bacterial diseases; Humans; Infectious diseases; Insulin resistance; Insulin Resistance - physiology; Male; Medical sciences; Middle Aged; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Resistance; Spirillales; Helicobacter pylori; Gastroenterology; Spirillaceae; Bacteria; Metabolic diseases; Insulin; insulin resistance
• ISSN: 0163-2116; 1573-2568
• DOI: 10.1007/s10620-005-3012-z

Helicobacter pylori causes a lifelong infection in the stomach after exposure. H. pylorihas been shown to be associated with peptic ulcer and gastric cancer development. Moreover, it is held responsible for some other nongastric diseases. Among them, coronary heart disease attracts much debate. Many studies have demonstrated a close relationship between insulin resistance and atherosclerosis. Chronic inflammation and alterations in counter-regulatory hormones are deemed responsible for the etiology of insulin resistance. We aimed to examine the effect of H. pylori on insulin resistance. Sixty-three patients were enrolled in the study. Patients were divided into two groups according to H. pylori presence. HOMA-IR (homeostasis model assessment of insulin resistance) level was used to assess insülin resistance. Thirty-six patients were H. pylori positive and 27 were H. pylori negative. There was no difference between the two groups with regard to age, gender, or body mass index. HOMA-IR level was 1.73+/- 1.1 in the H. pylori-negative group, whereas it was 2.56 +/- 1.54 in the H. pylori-positive group (P < 0.05). This study provides the first direct evidence for an association between chronic H. pylori infection and insulin resistance.