Biological safety and B cells activation effects of Zanthoxylum schinifolium
Zanthoxylum schinifolium has been used as culinary applications in Asia and some of its elements have been elucidated to have various pharmaceutical effects such as anti-platelet aggregation, inhibitory activities against monoamine oxidase, antioxidant and anticancer activities, and anti-inflammator...
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Published in | Molecular & cellular toxicology Vol. 7; no. 2; pp. 157 - 162 |
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Main Authors | , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Heidelberg
The Korean Society of Toxicogenomics and Toxicoproteomics
01.06.2011
대한독성 유전단백체 학회 |
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Abstract | Zanthoxylum schinifolium
has been used as culinary applications in Asia and some of its elements have been elucidated to have various pharmaceutical effects such as anti-platelet aggregation, inhibitory activities against monoamine oxidase, antioxidant and anticancer activities, and anti-inflammatory activity. In this study 21-day repeated
Zanthoxylum schinifolium
oral administration (250 mg/kg/day, once a day) modulated B cell-related immunity and biologically safe. After 21-day repeated oral administration, the expression of CD19 bound cells was significantly increased compared to those of the other surface molecules and the percentages of Alamar Blue® reduction were in LPS-treated splenocytes higher than in no treated but it was not different with in Con A-treated splenocytes and in no treated. Twenty-one-day repeated
Z. schinifolium
administration could not change the index of biological safety such as CBC, hematological enzymes, and especially histopathological morphologies. From the results
Z. schinifolium
-repeated administration enhances B cell immunity and is biological safe. Conclusively
Z. schinifolium
is one of the safe candidates to modulate immunity. |
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AbstractList | Zanthoxylum schinifolium
has been used as culinary applications in Asia and some of its elements have been elucidated to have various pharmaceutical effects such as anti-platelet aggregation, inhibitory activities against monoamine oxidase, antioxidant and anticancer activities, and anti-inflammatory activity. In this study 21-day repeated
Zanthoxylum schinifolium
oral administration (250 mg/kg/day, once a day) modulated B cell-related immunity and biologically safe. After 21-day repeated oral administration, the expression of CD19 bound cells was significantly increased compared to those of the other surface molecules and the percentages of Alamar Blue® reduction were in LPS-treated splenocytes higher than in no treated but it was not different with in Con A-treated splenocytes and in no treated. Twenty-one-day repeated
Z. schinifolium
administration could not change the index of biological safety such as CBC, hematological enzymes, and especially histopathological morphologies. From the results
Z. schinifolium
-repeated administration enhances B cell immunity and is biological safe. Conclusively
Z. schinifolium
is one of the safe candidates to modulate immunity. Zanthoxylum schinifolium has been used as culinary applications in Asia and some of its elements have been elucidated to have various pharmaceutical effects such as anti-platelet aggregation, inhibitory activities against monoamine oxidase, antioxidant and anticancer activities, and anti-inflammatory activity. In this study 21-day repeated Zanthoxylum schinifolium oral administration (250 mg/kg/day, once a day) modulated B cell-related immunity and biologically safe. After 21-day repeated oral administration,the expression of CD19 bound cells was significantly increased compared to those of the other surface molecules and the percentages of Alamar Blue® reduction were in LPS-treated splenocytes higher than in no treated but it was not different with in Con A-treated splenocytes and in no treated. Twenty-one-day repeated Z. schinifolium administration could not change the index of biological safety such as CBC, hematological enzymes, and especially histopathological morphologies. From the results Z. schinifolium-repeated administration enhances B cell immunity and is biological safe. Conclusively Z. schinifolium is one of the safe candidates to modulate immunity. KCI Citation Count: 3 |
Author | Lee, Yun Lyul De Xu, Hong Ahn, Jae-Bum Kim, Young-Jin Park, Yong-Il Jang, Soon-Ae Park, Sung Jin Lee, Jong-Hwa Park, Dae-Hun Lee, Min-Jae Li, Yong-Chun Cho, Soon-Chang |
Author_xml | – sequence: 1 givenname: Dae-Hun surname: Park fullname: Park, Dae-Hun organization: Korea Institute of Toxicology – sequence: 2 givenname: Yong-Il surname: Park fullname: Park, Yong-Il organization: College of Veterinary Medicine & Institute of Veterinary Science, Kangwon National University – sequence: 3 givenname: Yong-Chun surname: Li fullname: Li, Yong-Chun organization: College of Veterinary Medicine & Institute of Veterinary Science, Kangwon National University – sequence: 4 givenname: Hong surname: De Xu fullname: De Xu, Hong organization: School of Pharmaceutical Science, Zhengzhou University – sequence: 5 givenname: Jong-Hwa surname: Lee fullname: Lee, Jong-Hwa organization: Korea Institute of Toxicology – sequence: 6 givenname: Young-Jin surname: Kim fullname: Kim, Young-Jin organization: Traditional Food Research Group, Korea Food Research Institute – sequence: 7 givenname: Soon-Ae surname: Jang fullname: Jang, Soon-Ae organization: Center for Senior Industry, Youngdong University – sequence: 8 givenname: Sung Jin surname: Park fullname: Park, Sung Jin organization: Center for Senior Industry, Youngdong University – sequence: 9 givenname: Yun Lyul surname: Lee fullname: Lee, Yun Lyul organization: Department of Physiology, College of Medicine, Hallym University – sequence: 10 givenname: Jae-Bum surname: Ahn fullname: Ahn, Jae-Bum organization: College of Veterinary Medicine & Institute of Veterinary Science, Kangwon National University – sequence: 11 givenname: Soon-Chang surname: Cho fullname: Cho, Soon-Chang email: chan2337@paran.com organization: Center for Senior Industry, Youngdong University – sequence: 12 givenname: Min-Jae surname: Lee fullname: Lee, Min-Jae email: mjlee@kangwon.ac.kr organization: College of Veterinary Medicine & Institute of Veterinary Science, Kangwon National University |
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Cites_doi | 10.1211/0022357021778637 10.1016/j.fsi.2003.09.004 10.1055/s-2002-20056 10.1021/jf0728101 10.1002/jccs.200200021 10.1248/bpb.28.802 10.1016/j.vph.2009.01.008 10.1146/annurev.iy.11.040193.001555 10.1016/0031-9422(95)00054-B 10.1016/0022-1759(94)90396-4 10.1007/s11130-008-0092-x |
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Snippet | Zanthoxylum schinifolium
has been used as culinary applications in Asia and some of its elements have been elucidated to have various pharmaceutical effects... Zanthoxylum schinifolium has been used as culinary applications in Asia and some of its elements have been elucidated to have various pharmaceutical effects... |
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SubjectTerms | Biomedical and Life Sciences Cell Biology Life Sciences Original Paper Pharmacology/Toxicology 생물학 |
Title | Biological safety and B cells activation effects of Zanthoxylum schinifolium |
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