Biological safety and B cells activation effects of Zanthoxylum schinifolium

• Published in: Molecular & cellular toxicology Vol. 7; no. 2; pp. 157 - 162
• Main Authors: Park, Dae-Hun, Park, Yong-Il, Li, Yong-Chun, De Xu, Hong, Lee, Jong-Hwa, Kim, Young-Jin, Jang, Soon-Ae, Park, Sung Jin, Lee, Yun Lyul, Ahn, Jae-Bum, Cho, Soon-Chang, Lee, Min-Jae
• Format: Journal Article
• Language: English
• Published: Heidelberg The Korean Society of Toxicogenomics and Toxicoproteomics 01.06.2011; 대한독성 유전단백체 학회
• Subjects: Biomedical and Life Sciences; Cell Biology; Life Sciences; Original Paper; Pharmacology/Toxicology; 생물학; B cell immunity; Biological safety; Mice
• ISSN: 1738-642X; 2092-8467
• DOI: 10.1007/s13273-011-0021-1

Zanthoxylum schinifolium has been used as culinary applications in Asia and some of its elements have been elucidated to have various pharmaceutical effects such as anti-platelet aggregation, inhibitory activities against monoamine oxidase, antioxidant and anticancer activities, and anti-inflammatory activity. In this study 21-day repeated Zanthoxylum schinifolium oral administration (250 mg/kg/day, once a day) modulated B cell-related immunity and biologically safe. After 21-day repeated oral administration, the expression of CD19 bound cells was significantly increased compared to those of the other surface molecules and the percentages of Alamar Blue® reduction were in LPS-treated splenocytes higher than in no treated but it was not different with in Con A-treated splenocytes and in no treated. Twenty-one-day repeated Z. schinifolium administration could not change the index of biological safety such as CBC, hematological enzymes, and especially histopathological morphologies. From the results Z. schinifolium -repeated administration enhances B cell immunity and is biological safe. Conclusively Z. schinifolium is one of the safe candidates to modulate immunity.