Treatment of adenovirus-associated haemorrhagic cystitis with ganciclovir

• Published in: Bone marrow transplantation (Basingstoke) Vol. 20; no. 11; pp. 997 - 999
• Main Authors: CHEN, F. E, LIANG, R. H. S, LO, J. Y, YUEN, K. Y, CHAN, T. K, PEIRIS, M
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing Group 01.12.1997
• Subjects: Adenoviridae - isolation & purification; Adenovirus Infections, Human - complications; Adenovirus Infections, Human - diagnosis; Adenovirus Infections, Human - drug therapy; Adenoviruses; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antigens, Viral - urine; Antiviral agents; Antiviral Agents - therapeutic use; Biological and medical sciences; Bone marrow; Bone Marrow Transplantation; Bone marrow, stem cells transplantation. Graft versus host reaction; Cystitis; Cystitis - drug therapy; Cystitis - etiology; Cystitis - virology; Fluorescent Antibody Technique, Indirect; Ganciclovir; Ganciclovir - therapeutic use; Hemorrhage; Hemorrhagic cystitis; Humans; Leukemia, Myeloid, Acute - complications; Leukemia, Myeloid, Acute - therapy; Male; Medical sciences; Middle Aged; Pharmacology. Drug treatments; Stem cell transplantation; Transfusions. Complications. Transfusion reactions. Cell and gene therapy; Acyclic nucleoside; Purine nucleoside; Transfusion; Adenoviridae; Homograft; Male; Hemorrhage; Ganciclovir; Bone marrow; Adult; Antiviral; Complication; Graft; Cystitis; Human; Urinary system disease; Acute; Malignant hemopathy; Urinary tract disease; Infection; Virus; Case study; Chemotherapy; Treatment; Viral disease; Bladder disease; Acute myelocytic leukemia
• ISSN: 0268-3369; 1476-5365
• DOI: 10.1038/sj.bmt.1700997

We report a 47-year-old bone marrow transplant recipient with haemorrhagic cystitis caused by adenovirus successfully treated with ganciclovir. This is the first report on the use of ganciclovir for the successful treatment of adenoviral infection. Shell vial culture may be more sensitive than conventional culture in the detection of adenovirus in such patients.