Ability of ceftibuten to induce the class-I β-lactamases of Enterobacter cloacae, Serratia marcescens, and Enterobacter aerogenes

Ceftibuten, like cefotaxime, was observed to be a weak inducer of the class-I β-lactamases of Enterobacter cloacae, Serratia marcescens, and Enterobacter aerogenes. In contrast, cefoxitin and imipenem induced these enzymes strongly at subinhibitory concentrations.

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Bibliographic Details
Published inDiagnostic microbiology and infectious disease Vol. 14; no. 1; pp. 85 - 87
Main Authors Papanicolaou, Genovefa A., Medeiros, Antone A.
Format Journal Article Conference Proceeding
LanguageEnglish
Published New York, NY Elsevier Inc 1991
Elsevier
Subjects
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
beta-Lactamases - biosynthesis
Biological and medical sciences
Cefotaxime - pharmacology
Cefoxitin - pharmacology
Ceftibuten
Cephalosporins - pharmacology
Enterobacter - drug effects
Enterobacter - enzymology
Enzyme Induction - drug effects
Imipenem - pharmacology
Medical sciences
Pharmacology. Drug treatments
Serratia marcescens - drug effects
Serratia marcescens - enzymology
Congress
Enterobacter cloacae
Enzyme
Induction
Enterobacter aerogenes
β-Lactamase
In vitro
Biological activity
Cephalosporin derivatives
Sensitivity resistance
Serratia marcescens
Bacteria
Antibacterial agent
Enterobacteriaceae
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Summary:Ceftibuten, like cefotaxime, was observed to be a weak inducer of the class-I β-lactamases of Enterobacter cloacae, Serratia marcescens, and Enterobacter aerogenes. In contrast, cefoxitin and imipenem induced these enzymes strongly at subinhibitory concentrations.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0732-8893
1879-0070
DOI:10.1016/0732-8893(91)90094-V