Role of viral chromatin structure in the regulation of herpes simplex virus 1 gene expression and replication

Herpes simplex virus 1 initially infects epithelial cells during the lytic phase of its infectious cycle, followed by establishment of the latent phase within neuronal cells. The two different phases of infection are characterized by distinct gene-expression profiles, involving a temporal gene-expre...

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Bibliographic Details
Published inFuture microbiology Vol. 4; no. 6; pp. 703 - 712
Main Authors Ingvarsdottir, Kristin, Blaho, John A
Format Journal Article
LanguageEnglish
Published England Future Medicine Ltd 01.08.2009
Subjects
Binding sites
Chromatin
Chromatin - physiology
chromatin insulator
DNA, Viral - metabolism
gene expression
Gene Expression Regulation, Viral
Genetics
herpes simplex virus
Herpes simplex virus 1
Herpesvirus 1, Human - physiology
histone modification
histone variant
Humans
Proteins
Viral infections
Virus Replication
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Summary:Herpes simplex virus 1 initially infects epithelial cells during the lytic phase of its infectious cycle, followed by establishment of the latent phase within neuronal cells. The two different phases of infection are characterized by distinct gene-expression profiles, involving a temporal gene-expression pattern during the lytic phase succeeded by a complete shutdown of all gene expression, except for one abundant transcript, during the latent phase. The mechanisms controlling these varying degrees of gene expression appear to involve regulation of the viral chromatin structure, presumably using many of the same tactics employed by the host cell.
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ISSN:1746-0913
1746-0921
1746-0913
DOI:10.2217/fmb.09.48