Reversal of aluminum-related bone disease after renal transplantation

We evaluated the course of severe aluminum-related bone disease (ARBD) after the first year of a successful renal transplantation (RTx) in 11 adult patients. Bone pain and muscle weakness, presented in all patients previously to RTx, subsided, and all were able to walk, even the ones who were confin...

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Bibliographic Details
Published inAmerican journal of nephrology Vol. 13; no. 1; p. 12
Main Authors David-Neto, E, Jorgetti, V, Soeiro, N M, Pereira, R C, Borelli, A, Ianhez, L E, Sabbaga, E, Wajchemberg, B L, Arap, S
Format Journal Article
LanguageEnglish
Published Switzerland 1993
Subjects
Adult
Aluminum - metabolism
Bone and Bones - metabolism
Bone and Bones - pathology
Bone and Bones - physiopathology
Bone Density
Calcification, Physiologic
Calcium - blood
Chronic Kidney Disease-Mineral and Bone Disorder - metabolism
Chronic Kidney Disease-Mineral and Bone Disorder - pathology
Chronic Kidney Disease-Mineral and Bone Disorder - physiopathology
Creatinine - blood
Female
Humans
Kidney Transplantation
Male
Middle Aged
Osteogenesis
Osteomalacia - metabolism
Osteomalacia - pathology
Osteomalacia - physiopathology
Phosphorus - blood
Postoperative Period
Prospective Studies
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Summary:We evaluated the course of severe aluminum-related bone disease (ARBD) after the first year of a successful renal transplantation (RTx) in 11 adult patients. Bone pain and muscle weakness, presented in all patients previously to RTx, subsided, and all were able to walk, even the ones who were confined to wheelchairs. Bone necrosis developed in 6 patients, but none required surgical repair. Serum alkaline phosphatase activity increased 2.5 times the upper normal level, up to the 5th month and then declined to normal levels up the 12th month (p < 0.05). The inverse profile was observed in both serum calcium and phosphorus levels. In bone biopsies, there was a significant decrease in all of the following histomorphometric static parameters: osteoid volume, thickness and surface and also in aluminum surface. Also, there was a significant increase in all the dynamic parameters of mineralization: mineral apposition rate, mineralization surface, bone formation rate and adjusted apposition rate. In conclusion, ARBD remarkably improves after 1 year of successful RTx.
ISSN:0250-8095
DOI:10.1159/000168583