SARS-CoV-2 screening of asymptomatic women admitted for delivery must be performed with a combination of microbiological techniques: an observational study

• Published in: Revista española de quimioterapia Vol. 33; no. 6; pp. 415 - 421
• Main Authors: Viñuela, M C, De León-Luis, J A, Alonso, R, Catalán, P, Lizarraga, S, Muñoz, P, Bouza, E
• Format: Journal Article
• Language: English
• Published: Spain Sociedad Española de Quimioterapia 01.12.2020
• Subjects: Adolescent; Adult; Antibodies, Viral - blood; Asymptomatic Infections; Cesarean Section - statistics & numerical data; Coronavirus Nucleocapsid Proteins - immunology; COVID-19 - blood; COVID-19 - diagnosis; COVID-19 Nucleic Acid Testing; COVID-19 Serological Testing; Delivery, Obstetric - methods; Delivery, Obstetric - statistics & numerical data; Female; Humans; Immunoglobulin G - blood; Nasopharynx - virology; Original; Parturition; Phosphoproteins - immunology; Pregnancy; Pregnancy Complications, Infectious - blood; Pregnancy Complications, Infectious - diagnosis; Reverse Transcriptase Polymerase Chain Reaction; SARS-CoV-2 - immunology; Young Adult; SARS-CoV2; delivery; screening; RT-PCR; specific antibodies; cycle threshold
• ISSN: 0214-3429; 1988-9518
• DOI: 10.37201/req/088.2020

The aim of this study is to assess the value of systematic screening in asymptomatic women admitted for spontaneous delivery with a combination of reverse transcription polymerase chain reaction (RT-PCR) and cycle threshold (Ct) and serum antibodies. Since May 6 all women admitted for spontaneous delivery underwent RT-PCR in nasopharyngeal swabs and specific antibodies IgG of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in serum that were performed as part of routine clinical care in our institution. Ct of the PCR was recorded. We analyzed the first 100 women consecutively admitted for spontaneous delivery at our institution. Nine women were positive for SARS-CoV-2 in nasopharyngeal samples (9%) and 13 (13%) presented positive specific antibodies of the coronavirus. Overall, SARS-CoV-2 prior exposure was 15%. The Ct determination (RT-PCR test) of our 9 positive patients ranged from 36 to 41 cycles with a median of 40. Vaginal delivery occurred in 94% of the cases and only 6% underwent a cesarean section, always for obstetric reasons. No fetal transmission was observed and maternal and neonatal prognosis was excellent. During epidemic episodes in asymptomatic women in labor, universal testing with RT-PCR (considering Ct determination), and the detection of antibodies, permits a better interpretation of the results and avoid unnecessary isolation procedures.