Mucin-type O-glycosylation is critical for vascular integrity

Vascular endothelial cells, in addition to many other mammalian cell types, express proteins that are highly modified with mucin-type O-glycosylation, a specific type of glycosylation that begins with the addition of an N-acetylgalactosamine moiety to serine or threonine residues within the peptide...

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Bibliographic Details
Published inGlycobiology (Oxford) Vol. 24; no. 12; pp. 1237 - 1241
Main Authors Herzog, Brett H, Fu, Jianxin, Xia, Lijun
Format Journal Article
LanguageEnglish
Published England Oxford University Press 01.12.2014
Subjects
Animals
Endothelium, Vascular - metabolism
Glycosylation
Humans
Mucins - chemistry
Mucins - metabolism
Polysaccharides - metabolism
Special Issue–Reviews on Glycans in Vascular Biology
Clec-2
O-glycosylation
platelet
vascular integrity
podoplanin
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Summary:Vascular endothelial cells, in addition to many other mammalian cell types, express proteins that are highly modified with mucin-type O-glycosylation, a specific type of glycosylation that begins with the addition of an N-acetylgalactosamine moiety to serine or threonine residues within the peptide backbone. Recently, it has become evident that O-glycosylation governs the separation of blood and lymphatic vessels throughout life and plays a critical role in maintaining vascular integrity in specific tissues such as the brain and lymph node. This mini-review seeks to highlight some of these recent advances regarding in vivo functions of mucin-type O-glycans.
Bibliography:ObjectType-Article-2
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ObjectType-Review-1
ISSN:0959-6658
1460-2423
DOI:10.1093/glycob/cwu058