A drug delivery system based on switchable photo-controlled p-coumaric acid derivatives anchored on mesoporous silica

• Published in: Journal of materials chemistry. B, Materials for biology and medicine Vol. 5; no. 4; pp. 817 - 825
• Main Authors: Beňová, Eva, Zeleňák, Vladimír, Halamová, Dáša, Almáši, Miroslav, Petrul'ová, Veronika, Psotka, Miroslav, Zeleňáková, Adriána, Bačkor, Martin, Hornebecq, Virginie
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 2017
• Subjects: Chemical Sciences; Derivatives; Drug delivery systems; Grafting; Irradiation; Material chemistry; Naproxen; Porosity; Silicon dioxide
• ISSN: 2050-750X; 2050-7518
• DOI: 10.1039/c6tb02040b

A stimuli-responsive drug delivery system consisting of mesoporous silica with its surface modified by p-coumaric acid derivatives (CA) as photo-switchable ligands was studied for the delivery of the non-steroidal anti-inflammatory drug (NSAID) naproxen. For this purpose, MCM-41 mesoporous silica material was prepared and post-synthetically modified by the grafting of a triethoxysilyl derivative of p-coumaric acid, which undergoes a reversible photo-dimerization under UV irradiation and creates the "valves" on the surface of silica allowing targeted opening/closing of the pores. Naproxen was encapsulated into grafted MCM-41 and drug release studies were performed in two different media, in a simulated gastric fluid (pH = 2) and in a simulated body fluid (pH = 7.4). Differences in drug release were observed after irradiation of the material using UV light at λ = 365 nm (closed pore configuration) and UV light at λ = 254 nm (opened pore configuration).