Nifedipine enhances the cardiac toxicity of magnesium sulfate in the isolated perfused Sprague-Dawley rat heart

Magnesium sulfate is commonly used in tocolytic regimens and as prophylaxis against seizures. Nifedipine may be used simultaneously in either situation. With the isolated perfused rat heart model (Sprague-Dawley rats), we investigated the effects of these agents on cardiac function. Whereas each age...

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Bibliographic Details
Published inAmerican journal of obstetrics and gynecology Vol. 163; no. 2; p. 655
Main Authors Thorp, Jr, J M, Spielman, F J, Valea, F A, Payne, F G, Mueller, R A, Cefalo, R C
Format Journal Article
LanguageEnglish
Published United States 01.08.1990
Subjects
Animals
Depression, Chemical
Drug Interactions
Heart - drug effects
Magnesium Sulfate - pharmacology
Magnesium Sulfate - toxicity
Nifedipine - pharmacology
Nifedipine - toxicity
Perfusion
Rats
Rats, Inbred Strains
Tocolytic Agents
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Summary:Magnesium sulfate is commonly used in tocolytic regimens and as prophylaxis against seizures. Nifedipine may be used simultaneously in either situation. With the isolated perfused rat heart model (Sprague-Dawley rats), we investigated the effects of these agents on cardiac function. Whereas each agent alone depressed cardiac performance, the two drugs together had maximal depressive effects on the heart.
ISSN:0002-9378
DOI:10.1016/0002-9378(90)91218-2