Effects of acute stimulation through contacts placed on the motor cortex for chronic stimulation

• Published in: Clinical neurophysiology Vol. 113; no. 5; pp. 635 - 641
• Main Authors: HANAJIMA, R, ASHBY, P, LANG, A. E, LOZANO, A. M
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Science 01.05.2002
• Subjects: Adult; Aged; Awareness; Biological and medical sciences; Electric Impedance; Electric Stimulation Therapy; Electrodiagnosis. Electric activity recording; Electromyography; Female; Humans; Investigative techniques, diagnostic techniques (general aspects); Male; Medical sciences; Middle Aged; Motor Cortex - cytology; Motor Cortex - physiology; Motor Neurons - physiology; Movement Disorders - physiopathology; Movement Disorders - therapy; Multiple System Atrophy - physiopathology; Multiple System Atrophy - therapy; Nervous system; Neural Inhibition; Reaction Time; Facilitation; Human; Subdural; Nervous system diseases; Motor pathway; Electrical stimulus; Corticospinal bundle; Motor neuron; Involuntary movement; Pyramidal motor pathway; Motor cortex; Central nervous system disease; Multiple system atrophy; Motor evoked potential
• ISSN: 1388-2457; 1872-8952
• DOI: 10.1016/S1388-2457(02)00042-1

We tried to determine which neural elements were activated in awake subjects by stimulation through contacts placed chronically on the motor cortex. We recorded the motor effects of stimulation through 4 disc contacts placed in the subdural space over the motor cortex in 9 patients undergoing chronic stimulation for the control of pain or for the control of the rigidity of multiple system atrophy. Single stimuli could elicit short latency motor evoked potentials or facilitate active motoneurons in the contralateral limbs. The responsible neural elements had a short chronaxie (the pulse duration necessary to reach threshold with a stimulus intensity twice that required to reach threshold at the longest pulse duration used) and refractory period implying that they were myelinated axons. The facilitation was larger with cathodal than with anodal monopolar stimulation. The short latency facilitation in response to the second of two stimuli was greater at condition test intervals of 2-5 ms. This enhancement could be demonstrated with conditioning stimuli subthreshold for the excitation of active motoneurons suggesting that it arose, in part, at the level of the cortex. Single cortical stimuli could result in inhibition of voluntarily activated motoneurons. The inhibition was larger with cathodal than anodal monopolar stimulation. The responsible neural elements also had a short chronaxie and refractory period. Stimulation in awake subjects through contacts placed chronically over the motor cortex appears to activate axons in the cortex, which excite both corticospinal neurons and inhibitory neurons.