Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression

• Published in: Carcinogenesis (New York) Vol. 36; no. Suppl 1; pp. S2 - S18
• Main Authors: Nahta, Rita, Al-Mulla, Fahd, Al-Temaimi, Rabeah, Amedei, Amedeo, Andrade-Vieira, Rafaela, Bay, Sarah N., Brown, Dustin G., Calaf, Gloria M., Castellino, Robert C., Cohen-Solal, Karine A., Colacci, Anna Maria, Cruickshanks, Nichola, Dent, Paul, Di Fiore, Riccardo, Forte, Stefano, Goldberg, Gary S., Hamid, Roslida A., Krishnan, Harini, Laird, Dale W., Lasfar, Ahmed, Marignani, Paola A., Memeo, Lorenzo, Mondello, Chiara, Naus, Christian C., Ponce-Cusi, Richard, Raju, Jayadev, Roy, Debasish, Roy, Rabindra, Ryan, Elizabeth P., Salem, Hosni K., Scovassi, A.Ivana, Singh, Neetu, Vaccari, Monica, Vento, Renza, Vondráček, Jan, Wade, Mark, Woodrick, Jordan, Bisson, William H.
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.06.2015
• Subjects: Animals; Environmental Exposure - adverse effects; Hazardous Substances - adverse effects; Humans; Neoplasms - chemically induced; Neoplasms - etiology; Review; Signal Transduction - drug effects
• ISSN: 0143-3334; 1460-2180
• DOI: 10.1093/carcin/bgv028

As part of the Halifax Project, this review brings attention to the potential effects of environmental chemicals on important molecular and cellular regulators of the cancer hallmark of evading growth suppression. Specifically, we review the mechanisms by which cancer cells escape the growth-inhibitory signals of p53, retinoblastoma protein, transforming growth factor-beta, gap junctions and contact inhibition. We discuss the effects of selected environmental chemicals on these mechanisms of growth inhibition and cross-reference the effects of these chemicals in other classical cancer hallmarks.