Substratum regulation of neurite fasciculation

A new clonal nerve-like cell line from the rat eye is used to show that cell-substratum adhesion can modulate neurite fasciculation. When cells are grown on a substratum of intermediate adhesiveness their neurites adhere to each other and form fascicles. In contrast, cells grown on more adhesive sur...

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Bibliographic Details
Published inBrain research Vol. 549; no. 2; p. 305
Main Authors Schubert, D, Klier, F G
Format Journal Article
LanguageEnglish
Published Netherlands 24.05.1991
Subjects
Animals
Axons - physiology
Cell Adhesion
Cell Line
Chemotaxis - drug effects
Clone Cells
Eye - cytology
Leucine - metabolism
Microscopy, Electron
Neurons - physiology
Rats
Tumor Cells, Cultured - ultrastructure
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Summary:A new clonal nerve-like cell line from the rat eye is used to show that cell-substratum adhesion can modulate neurite fasciculation. When cells are grown on a substratum of intermediate adhesiveness their neurites adhere to each other and form fascicles. In contrast, cells grown on more adhesive surfaces spread and extend individual neurites. The direct relationship between the initial rates of cell-substratum adhesion and neurite fasciculation shows that the extent of axon fasciculation which occurs in vivo may be determined by the extracellular environment through which the axons are growing.
ISSN:0006-8993
1872-6240
DOI:10.1016/0006-8993(91)90472-8