Independent evidence for a commitment model of clonal attenuation

We previously reported a model of clonal attenuation which assumes three classes of cells: small highly replicative cells; intermediate size cells of limited replicative potential and large non-dividing cells. Computer simulations carried out with the model lead to predictions of how the relative pr...

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Bibliographic Details
Published inMechanisms of ageing and development Vol. 49; no. 3; pp. 281 - 286
Main Authors Angello, John C., Prothero, John
Format Journal Article
LanguageEnglish
Published Shannon Elsevier Ireland Ltd 01.09.1989
Elsevier Science
Subjects
Biological and medical sciences
Cell cycle, cell proliferation
Cell physiology
Clonal attenuation
Clone Cells
Fibroblast
Fundamental and applied biological sciences. Psychology
Humans
In vitro
Models, Biological
Molecular and cellular biology
Size
Clonal attenuation
Model
Fibroblast
In vitro
Size
Cell division
Cell culture
Models
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Summary:We previously reported a model of clonal attenuation which assumes three classes of cells: small highly replicative cells; intermediate size cells of limited replicative potential and large non-dividing cells. Computer simulations carried out with the model lead to predictions of how the relative proportion of each cell type varies throughout the in vitro replicative life span of a mass population. These predictions appear to be broadly confirmed by independent data recently reported by another laboratory.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0047-6374
1872-6216
DOI:10.1016/0047-6374(89)90078-X