Fragile phagocytes: FMRP positively regulates engulfment activity

Defective immune system function is implicated in autism spectrum disorders, including Fragile X syndrome. In this issue, O'Connor et al. (2017. https://doi.org/10.1083/jcb.201607093) demonstrate that phagocytic activity of systemic immune cells is compromised in a model of Fragile X, highlight...

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Bibliographic Details
Published inThe Journal of cell biology Vol. 216; no. 3; pp. 531 - 533
Main Author Logan, Mary A
Format Journal Article
LanguageEnglish
Published United States The Rockefeller University Press 06.03.2017
Subjects
Animals
Drosophila melanogaster - immunology
Drosophila melanogaster - metabolism
Drosophila Proteins - metabolism
Fragile X Mental Retardation Protein - metabolism
Fragile X Syndrome - immunology
Fragile X Syndrome - metabolism
Immunity, Innate - immunology
Phagocytes - immunology
Phagocytes - metabolism
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Summary:Defective immune system function is implicated in autism spectrum disorders, including Fragile X syndrome. In this issue, O'Connor et al. (2017. https://doi.org/10.1083/jcb.201607093) demonstrate that phagocytic activity of systemic immune cells is compromised in a model of Fragile X, highlighting intriguing new mechanistic connections between FMRP, innate immunity, and abnormal development.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0021-9525
1540-8140
DOI:10.1083/jcb.201702034