Cytotoxic Bioactivity of Some Phenylpropanoic Acid Derivatives

In this study, we synthesized a series of phenylpropanoic acid derivatives based on modifications at four selected points of the molecular scaffold. The in vitro antiproliferative activities of the compounds were examined in representative human solid tumor cell lines. A SAR was established pointing...

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Bibliographic Details
Published inNatural product communications Vol. 7; no. 10; pp. 1341 - 1346
Main Authors Reta, Guillermo F., Tonn, Carlos E., Ríos-Luci, Carla, León, Leticia G., Pérez-Roth, Eduardo, Padrón, José M., Donadel, Osvaldo J.
Format Journal Article
LanguageEnglish
Published Los Angeles, CA SAGE Publications 01.10.2012
Subjects
Antineoplastic Agents, Phytogenic - chemical synthesis
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - pharmacology
Cell Line, Tumor
Cell Survival - drug effects
Chromatography, Thin Layer
Drug Screening Assays, Antitumor
Gas Chromatography-Mass Spectrometry
Humans
Indicators and Reagents
Magnetic Resonance Spectroscopy
Phenylpropionates - chemical synthesis
Phenylpropionates - chemistry
Phenylpropionates - pharmacology
Spectrophotometry, Infrared
Structure-Activity Relationship
Structure-activity relationship
Phenylpropanoic acids
Antitumor
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Summary:In this study, we synthesized a series of phenylpropanoic acid derivatives based on modifications at four selected points of the molecular scaffold. The in vitro antiproliferative activities of the compounds were examined in representative human solid tumor cell lines. A SAR was established pointing out the relevance of the substituents. The best activity profiles were obtained for the derivatives bearing more lipophilic esters (GI50 3.1-21 μM).
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1934-578X
1555-9475
DOI:10.1177/1934578X1200701023