Biochemical, structural characterization and assessing the biological effects of cinnamon nanoparticles

• Published in: Biotechnology and bioprocess engineering Vol. 29; no. 1; pp. 165 - 175
• Main Authors: Sabouri, Zahra, Shakour, Neda, Sabouri, Mohammad, Tabrizi Hafez Moghaddas, Samaneh Sadat, Darroudi, Majid
• Format: Journal Article
• Language: English
• Published: Seoul The Korean Society for Biotechnology and Bioengineering 01.02.2024; Springer Nature B.V; 한국생물공학회
• Subjects: Anticancer properties; Biological effects; Biotechnology; Chemistry; Chemistry and Materials Science; Cinnamon; Diabetes mellitus; Fourier transform infrared spectroscopy; Fourier transforms; Glucose; Industrial and Production Engineering; Infrared analysis; Light diffraction; Light scattering; Morphology; Nanoparticles; Photon correlation spectroscopy; Pioglitazone; Research Paper; Structural analysis; Therapeutic applications; therapeutics; Transmission electron microscopy; water solubility; X-ray diffraction; 생물공학; Green synthesis; Cinnamon nanoparticles; Glucose; Antidiabetic activity; Hydrothermal
• ISSN: 1226-8372; 1976-3816
• DOI: 10.1007/s12257-024-00004-w

The natural polyphenolic materials that cinnamon contains are well known for their different biological applications and have a wide variety of pharmacological and therapeutic attributes. Bioactive and harmless cinnamon nanoparticles (cinnamon-NPs) can be anticancer and antidiabetic agents. For this purpose, water-soluble cinnamon-NPs were synthesized using the hydrothermal technique for the first time and in vitro studies were performed to investigate their anti-diabetic effects. The outcomes of morphology, size, and stability of cinnamon-NPs were described through Transmission electron microscopy (TEM), X-ray diffraction (XRD), Dynamic light scattering/Zeta (DLS/Zeta), Ultraviolet–visible (UV–Vis), and Fourier transform infrared (FTIR) analyses. The morphology of cinnamon-NPs was spherical and their average size was about 14.8 nm. Furthermore, the glucose consumption assay results revealed that compound cinnamon-NPs at 1.0 and 10 µM significantly lowered glucose levels ( p  < 0.05) in HepG2 cells exposed to 11.0 and 22.0 mM of glucose compared with standard (pioglitazone) and control groups. Therefore, the utilization of spherical NPs suspended in water could be useful for investigating therapeutic applications.