Body mass index and albumin levels are prognostic factors for long-term survival in elders with limited performance status

• Published in: Aging (Albany, NY.) Vol. 12; no. 2; pp. 1104 - 1113
• Main Authors: Lai, Kuan-Yu, Wu, Tai-Hsien, Liu, Chiu-Shong, Lin, Chih-Hsueh, Lin, Cheng-Chieh, Lai, Ming-May, Lin, Wen-Yuan
• Format: Journal Article
• Language: English
• Published: United States Impact Journals 16.01.2020
• Subjects: Aged; Aged, 80 and over; Body Mass Index; Female; Health Status; Humans; Kaplan-Meier Estimate; Longevity; Male; Mortality; Nutritional Status; Prognosis; Proportional Hazards Models; Research Paper; Serum Albumin, Human; mortality; performance status; elder; body mass index; albumin
• ISSN: 1945-4589; 1945-4589
• DOI: 10.18632/aging.102642

Elderly long-term care facility residents typically have musculoskeletal conditions that may lead to long-term disability and increased mortality. Our main objective was to explore the relationship between body mass index (BMI), albumin levels, and mortality in elderly individuals with limited performance status. Among 182 participants (mean age, 78.8 years; 57% women), 11%, 64%, and 25% had serum albumin levels of <2.8, 2.8-3.5, and >3.5 g/dL, respectively. After multivariate adjustments, diastolic blood pressure >90 mmHg was associated with all-cause mortality [hazard ratio (HR) = 2.08, 95% confidence interval (CI) = 1.13-3.82; P = 0.018]. In addition, BMI <18.5 kg/m2 and albumin level <2.8 g/dL associated with higher mortality than BMI = 18.5-24 kg/m2 and albumin level > 3.5 g/dL (HR = 1.80, 95% CI = 1.11-2.94 and HR = 2.54, 95% CI 1.22-5.30, respectively; P = 0.018 and 0.013, respectively). Highest mortality was noted in participants with albumin levels <2.8 g/dL and BMIs <18.5 kg/m2 (HR = 6.12, 95% CI = 1.85-20.21, P = 0.003). Combined hypoalbuminemia (albumin level < 2.8 g/dL) and low BMI (<18.5 kg/m2) may be a useful prognostic indicator of high mortality risk in elderly individuals with limited performance status.