Effects of steroid anaesthesia on some liver function tests in goats

• Published in: Journal of steroid biochemistry Vol. 32; no. 3; pp. 475 - 476
• Main Authors: Amer, Hassan A., Ahmed, Ahmed S., Gohar, Hany M., Abdel Mamid, Mohamed A.
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier B.V 01.03.1989; New York, NY Pergamon
• Subjects: Alanine Transaminase - blood; Alfaxalone Alfadolone Mixture - pharmacology; Anesthesia; Animals; Aspartate Aminotransferases - blood; Bilirubin - blood; Biological and medical sciences; Blood Glucose - metabolism; Blood Proteins - metabolism; Female; Fundamental and applied biological sciences. Psychology; Goats; Liver - drug effects; Liver - physiology; Liver. Bile. Biliary tracts; Male; Vertebrates: digestive system; Xylazine - pharmacology; Steroid; Enzyme; Steroid hormone; Liver; Glucose; Blood; Blood plasma; Vertebrata; Hyperglycemia; Mammalia; Enzymatic activity; Anesthesia; Goat; Artiodactyla; Mechanism of action; Ungulata; Quantitative analysis; Bile
• ISSN: 0022-4731
• DOI: 10.1016/0022-4731(89)90225-2

The effect of Saffan, a steroid anaesthetic, on the liver function of goats has been studied. Forty healthy animals were divided into 4 equal groups. The first 2 groups were given 2 and 4 mg Saffan/kg b. wt respectively. A mixture of Saffan (1 mg) and Xylazine (0.1 mg)/kg b. wt was given to the third group and Xylazine alone to the fourth group (0.1 mg/kg b. wt). Serum samples from all groups were analysed for glucose, total protein, total and direct bilirubin and the level of activity of transaminases. Administration of Saffan evoked more hyperglycemia than a mixture with Xylazine, or Xylazine alone. The hyperglycémie effect of both doses of Saffan (2 and 4 mg) was equivocal beyond 2 h. The effect then differed and glucose was increased 4-fold by 2 mg and 3-fold by 4 mg Saffan. Serum total protein, conjugated and total bilirubin, and GPT and GOT were not changed in the four experimental groups. This was good evidence of a normally functioning liver during the course of steroid anaesthesia administration in goats.