The effect of delayed anti-NMDAR encephalitis recognition on disease outcome

Anti-NMDA receptor encephalitis is an acute form of brain inflammation that is potentially lethal but has a high probability for recovery with treatment. Although the clinical picture of anti-NMDAR encephalitis is usually recognizable due to its relatively well-known symptoms, the disorder can somet...

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Published inJournal of neurovirology Vol. 24; no. 5; pp. 638 - 641
Main Authors Sulentic, Vlatko, Petelin Gadze, Zeljka, Derke, Filip, Santini, Marija, Bazadona, Danira, Nankovic, Sibila
Format Journal Article
LanguageEnglish
Published Cham Springer International Publishing 01.10.2018
Subjects
Biomedical and Life Sciences
Biomedicine
Case Report
Immunology
Infectious Diseases
Neurology
Neurosciences
Virology
Treatment outcome
Cognitive disorders
Anti-NMDAR encephalitis
Autoimmune encephalitis
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Summary:Anti-NMDA receptor encephalitis is an acute form of brain inflammation that is potentially lethal but has a high probability for recovery with treatment. Although the clinical picture of anti-NMDAR encephalitis is usually recognizable due to its relatively well-known symptoms, the disorder can sometimes present itself in an unpredictable and atypical way. In this case report, we wish to present the influence of different delay times prior to the establishment of diagnosis. Thus, our first patient was diagnosed with anti-NMDAR encephalitis 4 years after the initial symptoms, the second one after 8 years, and the third one after 13 months. The outcomes of the three presented patients indicate the importance of being aware of many clinical presentations of this disorder, as its early diagnosis greatly affects the outcome and may reduce permanent damage, especially in cognitive functions.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
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ObjectType-Report-1
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ISSN:1355-0284
1538-2443
DOI:10.1007/s13365-018-0648-y