Cytogenetics in autologous bone marrow transplantation

• Published in: Cancer genetics and cytogenetics Vol. 45; no. 1; pp. 137 - 138
• Main Authors: Maserati, Emanuela, Campagnoli, Elena, Truglio, F., Porta, F., Nespoli, L., Burgio, G.R., Pasquali, F.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.03.1990; Elsevier Science
• Subjects: acute lymphatic leukemia; Biological and medical sciences; Bone Marrow - ultrastructure; Bone Marrow Transplantation; Chromosome Aberrations; Hematologic and hematopoietic diseases; Humans; Infant; Leukemia-Lymphoma, Adult T-Cell - genetics; Leukemia-Lymphoma, Adult T-Cell - pathology; Leukemia-Lymphoma, Adult T-Cell - surgery; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Male; Medical sciences; Recurrence; Chromosomal aberration; Human; Recurrence; Malignant hemopathy; Autotransplantation; Treatment; T-Lymphocyte; Cytogenetics; Bone marrow; Abnormal chromosome; Diagnosis; Acute lymphocytic leukemia; Child; Chromosome translocation
• ISSN: 0165-4608; 1873-4456
• DOI: 10.1016/0165-4608(90)90077-N

C.F., a boy born in 1985, was diagnosed as having T-cell ALL of the L1 type (French-American-British (FAB) classification) in May 1987, when a chromosome analysis of bone marrow showed a translocation between the chromosomes 3 and 5 as the sole acquired anomaly. The karyotype was 46,XY,t(3; 5)(q25; q22)/46,XY (Table 1). In January 1988, the morphological picture of a marrow biopsy indicated complete remission, and bone marrow cells were harvested for ABMT. A chromosomal analysis of this material showed one cell with the translocation (3; 5) among the 36 cells examined. As a consequence ABMT was not performed and a severe relapse of the disease occurred in the following months, with evident proliferation of the clone with the t(3; 5).