Evaluation of amino acid profile in serum of patients with Covid-19 for providing a new treatment strategy

• Published in: Journal of medical biochemistry Vol. 41; no. 4; pp. 526 - 533
• Main Authors: Ozturk, Ali, Bayraktar, Nihayet, Bayraktar, Mustafa, Ibrahim, Bashar, Bozok, Taylan, Resat, Ceylan
• Format: Journal Article
• Language: English
• Published: Society of Medical Biochemists of Serbia, Belgrade 01.01.2022
• Subjects: amino acid; covid-19; Original Paper; sars-cov-2; treatment strategy
• ISSN: 1452-8258; 1452-8266
• DOI: 10.5937/jomb0-37514

Background: Amino acids have an important role in metabolism and may affect COVID-19-related outcomes. In our study, the amino acid serum level of hospitalized COVID19 patients was evaluated to determine a new treatment strategy. Methods: The amino acid profile covering 43 amino acids in 68 subjects, comprising 30 (14 men and 16 women) controls and 38 (16 men and 22 women) COVID-19 patients, were examined. The amino acid profiles of the participants were screened by LC-MS/MS. Results: Compared with the control group, serum levels of 27 amino acids increased in the patient group. Alpha-aminopimelic acid, sarcosine, and hydroxyproline amino acids were considerably higher in the control group than in the patient group (p<0.0001). There was no notable difference among control group and the case group for 13 amino acids (p≥0.05). A significant positive correlation was seen among the control and the patient groups in the mean amino acid values (r=0.937; p<0.0001). Conclusions: These results postulated a clear picture on the serum levels of amino acid in the COVID-19 patients. Serum amino acids measured in hospitalized COVID-19 patients can explain the patient's metabolic status during the disease.