New insights into the surface Enhanced Raman Scattering (SERS) response of adenine using chemometrics

• Published in: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy Vol. 314; p. 124177
• Main Authors: Percot, A., Maurel, M.C., Lambert, J.F., Zins, E.L.
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 05.06.2024; Elsevier
• Subjects: Adenine; Aggregating salt; Creighton's colloid; Independent Component Analysis (ICA); Life Sciences; Surface Enhanced Raman Scattering (SERS); Trace analysis; Trace analysis; Adenine; Aggregating salt; Surface Enhanced Raman Scattering (SERS); Creighton's colloid; Independent Component Analysis (ICA); Surface Enhanced Raman Scattering (SERS) ,Adenine ,Creighton's colloid, Independent Component Analysis (ICA) ,Aggregating salt ,Trace analysis
• ISSN: 1386-1425; 1873-3557
• DOI: 10.1016/j.saa.2024.124177

[Display omitted] •Evidence of the influence of measurement conditions on the SERS signature of adenine.•Disruption of silver colloid stability to amplify Raman signal enhancement.•Use of Independent Component Analysis for a more rational processing of spectra.•Improving SERS response understanding. The SERS response of adenine is one of the most studied, due to its outstanding exaltation. However, the spectra obtained strongly differ according to the experimental conditions and still remain not well understood. To be able to search for the presence of this molecule in complex environments, it is essential to better understand the SERS response of adenine alone. After a brief presentation of the literature on the subject, we present results suggesting that the experimental spectra would result from the overlap of different spectroscopic signatures, that may probably be due to different non-covalent interactions or different electromagnetic fields experienced by adenine molecules. An independent component analysis is reported. Our results underline the difficulty to precisely analyze the experimental data, the need to continue this research and to constitute data banks that would allow comparing the spectra obtained in different laboratories according to the experimental conditions.