Jejunal vasculitis with protein-losing enteropathy after bone marrow transplantation

A 37-yr-old white man experienced crampy abdominal pain beginning 21 days after successful bone marrow transplantation for chronic myelogenous leukemia. Generalized edema and hypoproteinemia developed. Symptoms persisted until 61 days post-transplant, when the patient developed an acute abdomen. At...

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Bibliographic Details
Published inGastroenterology (New York, N.Y. 1943) Vol. 98; no. 6; p. 1689
Main Authors Jafri, F M, Mendelow, H, Shadduck, R K, Sekas, G
Format Journal Article
LanguageEnglish
Published United States 01.06.1990
Subjects
Abdominal Pain - etiology
Adult
Bone Marrow Transplantation - adverse effects
Humans
Hypoproteinemia - etiology
Jejunal Diseases - etiology
Jejunum - blood supply
Jejunum - pathology
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - surgery
Male
Protein-Losing Enteropathies - etiology
Vasculitis - etiology
Vasculitis - pathology
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Summary:A 37-yr-old white man experienced crampy abdominal pain beginning 21 days after successful bone marrow transplantation for chronic myelogenous leukemia. Generalized edema and hypoproteinemia developed. Symptoms persisted until 61 days post-transplant, when the patient developed an acute abdomen. At laparotomy, an edematous segment of jejunum was resected. Pathological examination showed submucosal vasculitis and necrotizing enteritis. Serum protein and albumin levels returned to normal within a few weeks after surgery. Vasculitis of the gastrointestinal tract should be considered in the differential diagnosis of protein-losing enteropathy after bone marrow transplantation.
ISSN:0016-5085
DOI:10.1016/0016-5085(90)91108-I