Common drive to the upper airway muscle genioglossus during inspiratory loading

• Published in: Journal of neurophysiology Vol. 114; no. 5; pp. 2883 - 2892
• Main Authors: Woods, Michael J, Nicholas, Christian L, Semmler, John G, Chan, Julia K M, Jordan, Amy S, Trinder, John
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.11.2015
• Subjects: Adult; Electromyography; Humans; Inhalation; Male; Motor Neurons - physiology; Neural Circuits; Respiratory Muscles - innervation; Respiratory Muscles - physiology; motor neurons; obstructive sleep apnea; common drive; genioglossus; motor units
• ISSN: 0022-3077; 1522-1598
• DOI: 10.1152/jn.00738.2014

Common drive is thought to constitute a central mechanism by which the efficiency of a motor neuron pool is increased. This study tested the hypothesis that common drive to the upper airway muscle genioglossus (GG) would increase with increased respiratory drive in response to an inspiratory load. Respiration, GG electromyographic (EMG) activity, single-motor unit activity, and coherence in the 0-5 Hz range between pairs of GG motor units were assessed for the 30 s before an inspiratory load, the first and second 30 s of the load, and the 30 s after the load. Twelve of twenty young, healthy male subjects provided usable data, yielding 77 pairs of motor units: 2 Inspiratory Phasic, 39 Inspiratory Tonic, 15 Expiratory Tonic, and 21 Tonic. Respiratory and GG inspiratory activity significantly increased during the loads and returned to preload levels during the postload periods (all showed significant quadratic functions over load trials, P < 0.05). As hypothesized, common drive increased during the load in inspiratory modulated motor units to a greater extent than in expiratory/tonic motor units (significant load × discharge pattern interaction, P < 0.05). Furthermore, this effect persisted during the postload period. In conclusion, common drive to inspiratory modulated motor units was elevated in response to increased respiratory drive. The postload elevation in common drive was suggestive of a poststimulus activation effect.