Chemical Constituents of the Aerial Parts of Euphorbia Nematocypha

Chemical constituents of the dried aerial parts of Euphorbia nematocypha were investigated. A new oleanane triterpenoid, trans, trans-2′,4′-hexadienedioicacid-1′-β-amyrin ester (1), together with, β-amyrin (2), β-amyrin acetate (3), betulinic acid (4), ellagic acid (5), oleanolic acid (6), β-sitoste...

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Published inNatural product communications Vol. 11; no. 2; pp. 177 - 178
Main Authors Xu, Chen, Jia, Hai-Yang, Zuo, Bo, Liao, Zhi-Xin, Ji, Lan-Ju, Sun, Hong-Fa, Wang, Qi
Format Journal Article
LanguageEnglish
Published Los Angeles, CA SAGE Publications 01.02.2016
Subjects
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - pharmacology
Euphorbia - chemistry
Molecular Structure
Plant Components, Aerial - chemistry
Triterpenes - chemistry
Triterpenes - pharmacology
Antiproliferative
Euphorbia
Oleanane
Euphorbia nematocypha
Triterpenoid
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Summary:Chemical constituents of the dried aerial parts of Euphorbia nematocypha were investigated. A new oleanane triterpenoid, trans, trans-2′,4′-hexadienedioicacid-1′-β-amyrin ester (1), together with, β-amyrin (2), β-amyrin acetate (3), betulinic acid (4), ellagic acid (5), oleanolic acid (6), β-sitosterol (7), kaempferol (8), quercetin (9), lupeol (10) and pseudo-taraxasterol (11) were isolated from the methylene chloride extract. Their structures were elucidated on the basis of extensive spectroscopic (1D- & 2D-NMR) and ESI-MS analysis and comparison with data reported in the literature. The new isolated triterpenoid showed moderate cytotoxic activities against HeLa and MCF-7cell lines.
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ISSN:1934-578X
1555-9475
DOI:10.1177/1934578X1601100210