Preanesthetic medication with rectal midazolam in children undergoing dental extractions

• Published in: Journal of oral and maxillofacial surgery Vol. 48; no. 8; pp. 791 - 796
• Main Authors: Roelofse, J.A., Van Der Bijl, P., Stegmann, D.H., Hartshorne, J.E.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.08.1990; Elsevier
• Subjects: Administration, Rectal; Analysis of Variance; Anesthesia, Dental; Anesthesia, General; Biological and medical sciences; Chi-Square Distribution; Child; Child, Preschool; Dentistry; Double-Blind Method; Ent. Stomatology; Female; Humans; Male; Medical sciences; Midazolam - administration & dosage; Pharmacology. Drug treatments; Preanesthetic Medication; Randomized Controlled Trials as Topic; Tooth Extraction; Human; Chemotherapy; Treatment; Stomatology; Surgery; Anesthesia; Benzodiazepine derivatives; Extraction; Tooth; Child; Rectal administration; Premedication
• ISSN: 0278-2391; 1531-5053
• DOI: 10.1016/0278-2391(90)90333-W

Three different dosages (0.25, 0.35, and 0.45 mg/kg) of rectally administered midazolam were compared with each other and with placebo for preanesthetic medication in children undergoing dental extractions. Eighty patients between the ages of 2 and 10 years were randomly allocated into four groups in this double-blind study. The results from this trial show that 30 minutes after rectal administration of all doses of midazolam, good anxiolysis, sedation, and cooperation were obtained in most patients. A high prevalence (23%) of disinhibition reactions was observed, particularly in the 0.45 mg/kg group. For this reason, 0.25 or 0.35 mg/kg appears to be the dose of choice when rectal midazolam is used for premedication in children.