In Vivo Study of Cross-Sectional Skeletal Muscle Fiber Asymmetry with Diffusion-Weighted MRI

Skeletal muscles are highly organized hierarchical structures characterized by an anisotropic arrangement of muscle fibers (myocytes) in fascicles. Due to its unique non-invasive microstructure probing capabilities, diffusion-weighted Magnetic Resonance Imaging (DW-MRI) constitutes a valuable non-in...

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Bibliographic Details
Published in2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society Vol. 2007; pp. 327 - 330
Main Authors Karampinos, D.C., King, K.F., Sutton, B.P., Georgiadis, J.G.
Format Conference Proceeding Journal Article
LanguageEnglish
Published United States IEEE 01.01.2007
Subjects
Anisotropic magnetoresistance
Biological system modeling
Biological tissues
Diffusion Magnetic Resonance Imaging - methods
Encoding
Humans
Image Enhancement - methods
In vivo
Leg
Magnetic resonance imaging
Microarchitecture
Microstructure
Models, Biological
Muscle Fibers, Skeletal
Muscle, Skeletal - anatomy & histology
Muscles
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Summary:Skeletal muscles are highly organized hierarchical structures characterized by an anisotropic arrangement of muscle fibers (myocytes) in fascicles. Due to its unique non-invasive microstructure probing capabilities, diffusion-weighted Magnetic Resonance Imaging (DW-MRI) constitutes a valuable non-invasive tool in the study of such fibrous biological tissues. We have implemented a DW-MRI sequence with highly sensitive directional encoding to quantify the microarchitectural properties of human calf muscles at rest. We have specifically focused on a composite model-based analysis of diffusion tensor MRI measurements to quantify in vivo the cross-sectional asymmetry of muscle fiber geometry, which is a microstructural feature well documented in prior histological studies.
ISBN:9781424407873
1424407877
ISSN:1094-687X
1557-170X
1558-4615
DOI:10.1109/IEMBS.2007.4352290