Morphological and electrophysiological features of mature neurons in differentiated skin-derived precursor cells

In vitro modelling of neuronal pathologies is, in particular, demanding and a lot of efforts have been undertaken to differentiate skin derived precursor cells into neuronal cells. However, so far all attempts did not result in cells with functional features of neurons like the ability to generate a...

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Published inJournal of stem cells & regenerative medicine Vol. 8; no. 1; pp. 35 - 36
Main Authors Liebmann, L, Beetz, C, Thorwarth, M, Deufel, T, Hübner, Ca
Format Journal Article
LanguageEnglish
Published India Journal of Stem Cells and Regenerative Medicine 01.01.2012
Subjects
Brief Communication
stem cells
skin-derived precursors
neuronal differentiation
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Summary:In vitro modelling of neuronal pathologies is, in particular, demanding and a lot of efforts have been undertaken to differentiate skin derived precursor cells into neuronal cells. However, so far all attempts did not result in cells with functional features of neurons like the ability to generate action potentials or synaptic activity. Here, we report that simple modifications of the protocols result in neuronal cells that display action potentials and synaptic activity. We think that our observation is an important step to model individual neuronal pathologies in vitro.
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Contributions LL performed experiments; MT skin biopsies; CB, TD and CAH concept and preparation of the manuscript.
Competing interests The authors declare no competing financial interests.
Supplementary Information Supplementary materials and methods are linked to the online version of the article.
ISSN:0973-7154
0973-7154
DOI:10.46582/jsrm.0801006