An Equivocal SCC Lesion-Antiepileptic-Induced CLOCC

We present a case of a woman who reported to the emergency unit due to recurrent episodes of severe headache and collapse. MRI examination revealed no relevant findings apart from small meningioma of the right parietal region. The patient was diagnosed with epilepsy and received outpatient treatment...

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Published inBrain sciences Vol. 12; no. 3; p. 384
Main Authors Kuczyńska, Maryla, Zbroja, Monika, Cyranka, Weronika, Halczuk, Izabela, Kopyto, Ewa, Halczuk, Iwona, Drelich-Zbroja, Anna
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 13.03.2022
MDPI
Subjects
Alcohol
Case Report
Consciousness
Convulsions & seizures
Corpus callosum
COVID-19
cytotoxic edema
Cytotoxicity
Demyelination
Disease
Drug dosages
Electrolytes
Epilepsy
Fainting
Headaches
Hypoglycemia
Laboratories
Lesions
Lymphoma
Magnetic resonance imaging
Malnutrition
Meningioma
Metabolism
Metabolites
Multiple sclerosis
Patients
Spectrum analysis
splenium
Streptococcus infections
Substance abuse treatment
Trauma
Traumatic brain injury
Vitamin deficiency
epilepsy
magnetic resonance imaging
corpus callosum
splenium
cytotoxic edema
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Summary:We present a case of a woman who reported to the emergency unit due to recurrent episodes of severe headache and collapse. MRI examination revealed no relevant findings apart from small meningioma of the right parietal region. The patient was diagnosed with epilepsy and received outpatient treatment, which was changed due to poor toleration. A follow-up MRI was performed which revealed an isolated, focal lesion of the splenium of the corpus callosum. The patient underwent extensive laboratory testing and antiseizure medications were started again. Another MRI indicated substantial regression of the splenium of the corpus callosum (SCC) lesion. Both the complete clinical image and results of the diagnostic evaluation spoke in favor of cytotoxicity of the corpus callosum associated with anti-epileptic drug treatment. Pathologies involving the corpus callosum include congenital, demyelination, infection, neoplasm, trauma and vascular changes. Isolated, non-specific lesions of the splenium of corpus callosum usually indicate multiple sclerosis; however, other pathologies should be considered. Anti-epileptic drugs may evoke cytotoxic lesions of the corpus callosum (CLOCCs).
ISSN:2076-3425
2076-3425
DOI:10.3390/brainsci12030384