Protective effects of curcumin against human immunodeficiency virus 1 gp120 V3 loop-induced neuronal injury in rats

• Published in: Neural regeneration research Vol. 7; no. 3; pp. 171 - 175
• Main Authors: Gong, Zheng, Yang, Lijuan, Tang, Hongmei, Pan, Rui, Xie, Sai, Guo, Luyan, Wang, Junbin, Deng, Qinyin, Xiong, Guoyin, Xing, Yanyan, Dong, Jun
• Format: Journal Article
• Language: English
• Published: India Joint Laboratory for Brain Function and Health of Jinan University and the University of Hongkong, Guangzh%Department of Orthopedics, First Affiliated Hospital, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China 25.01.2012; Institute of Brain Research, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China; Department of Pathophysiology, Key Laboratory of State Administration of Traditional Chinese Medicine, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China; Medknow Publications & Media Pvt Ltd
• Subjects: caspase-3; Research and Report: Traditional Chinese Medicine and Neuroregeneration; 人类免疫缺陷病毒; 保护作用; 大鼠; 姜黄素; 海马神经元; 神经元损伤; 诱导; gp120 V3 loop; neural regeneration; mitochondrial membrane potential; human immunodeficiency virus-associated neurocognitive function; hippocampal neurons; caspase-3; curcumin
• ISSN: 1673-5374; 1876-7958
• DOI: 10.3969/j.issn.1673-5374.2012.03.002

Curcumin improves the learning and memory deficits in rats induced by the gp120 V3 loop. The present study cultured rat hippocampal neurons with 1 nM gp120 V3 loop and 1 μM curcumin for 24 hours. The results showed that curcumin inhibited the gp120 V3 loop-induced mitochondrial membrane potential decrease, reduced the mRNA expression of the pro-apoptotic gene caspase-3, and attenuated hippocampal neuronal injury.