Elevated concentrations of soluble E-selectin and vascular cell adhesion molecule-1 in NIDDM. Effect of intensive insulin treatment

• Published in: Diabetes care Vol. 21; no. 6; pp. 1008 - 1013
• Main Authors: ALBERTINI, J.-P, VALENSI, P, LORMEAU, B, AUROUSSEAU, M.-H, FERRIERE, F, ATTALI, J.-R, GATTEGNO, L
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.06.1998
• Subjects: Apolipoproteins - blood; Atherosclerosis; Biological and medical sciences; Biomarkers - blood; Blood & organ donations; Blood Glucose - metabolism; Calories; Cardiovascular disease; Cell adhesion & migration; Coronary Disease - blood; Diabetes; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - drug therapy; Diabetes Mellitus, Type 2 - immunology; Diabetic Angiopathies - blood; Diabetic Nephropathies - blood; Diabetic Neuropathies - blood; Diabetic Retinopathy - blood; E-Selectin - blood; Endocrine disorders; Endothelium; Female; Hormones. Endocrine system; Humans; Hypertension; Hypertension - blood; Hypoglycemic Agents - therapeutic use; Insulin; Insulin - therapeutic use; Leukocytes; Ligands; Lipids - blood; Lipoproteins - blood; Low density lipoprotein; Male; Medical sciences; Metabolism; Middle Aged; Pharmacology. Drug treatments; Reference Values; Research design; Vascular Cell Adhesion Molecule-1 - blood; France; Endocrinopathy; Human; Pancreatic hormone; Vascular cell adhesion molecule 1; Intensive care; Statistical analysis; Continuous; Subcutaneous; E Selectin; Non insulin dependent diabetes; Insulin; Blood plasma; Protein hormone; Chemotherapy; Treatment; Surveillance; Influence; Glycemia
• ISSN: 0149-5992; 1935-5548
• DOI: 10.2337/diacare.21.6.1008

Elevated concentrations of soluble E-selectin and vascular cell adhesion molecule-1 in NIDDM. Effect of intensive insulin treatment. J P Albertini , P Valensi , B Lormeau , M H Aurousseau , F Ferrière , J R Attali and L Gattegno Laboratory of Biochemistry and Cell Biology, Hôpital Avicenne, Bobigny, France. jean-paul.albertini@avc.ap-hop-paris.fr Abstract OBJECTIVE: To evaluate the effects of a 14-day intensive insulin therapy and short-term improvement of glycemic control on serum levels of soluble forms of adhesion molecules, i.e., intercellular adhesion molecule-1 (sICAM-1), vascular cell adhesion molecule-1 (sVCAM-1), and E-selectin (sE-selectin) in NIDDM patients with poor glycemic control. RESEARCH DESIGN AND METHODS: A total of 16 NIDDM patients were compared with 23 healthy subjects (control group) and investigated before and after intensive insulin treatment. RESULTS: On day 0, sE-selectin and sVCAM-1 levels were significantly higher in NIDDM patients than in nondiabetic control subjects (median 87, range 63-115; median 544, range 408-797 vs. 58, 43-80; 443, 395-573 ng/ml, respectively) (P < 0.008 in both cases). On day 15, the fall in sE-selectin levels was significant (P < 0.0001) and at a lesser extent in sVCAM-1 levels (64, 48-85; 506, 417-678 ng/ml, respectively); these levels reached values that no longer differed from those of control subjects (P = 0.23 and 0.15, respectively). Moreover, the fall in sE-selectin was positively associated with the change in LDL cholesterol and the improvement of glycemia. CONCLUSIONS: In poorly controlled NIDDM patients, sE-selectin levels are increased and significantly fall to normal after short-term improvement of glycemic control. This suggests that assaying sE-selectin makes it possible to detect endothelium activation and to follow its reversal with euglycemia.