The Cytoarchitecture of Domain-specific Regions in Human High-level Visual Cortex

• Published in: Cerebral cortex (New York, N.Y. 1991) Vol. 27; no. 1; pp. 146 - 161
• Main Authors: Weiner, Kevin S, Barnett, Michael A, Lorenz, Simon, Caspers, Julian, Stigliani, Anthony, Amunts, Katrin, Zilles, Karl, Fischl, Bruce, Grill-Spector, Kalanit
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.01.2017
• Subjects: Adult; Female; Humans; Male; Models, Anatomic; Models, Neurological; Nerve Net - cytology; Nerve Net - physiology; Original; Visual Cortex - cytology; Visual Cortex - physiology; Visual Perception - physiology; Young Adult; fusiform body area (FBA); fusiform face area (FFA); brain map; parahippocampal place area (PPA); cytoarchitecture; visual word form area (VWFA)
• ISSN: 1047-3211; 1460-2199
• DOI: 10.1093/cercor/bhw361

A fundamental hypothesis in neuroscience proposes that underlying cellular architecture (cytoarchitecture) contributes to the functionality of a brain area. However, this hypothesis has not been tested in human ventral temporal cortex (VTC) that contains domain-specific regions causally involved in perception. To fill this gap in knowledge, we used cortex-based alignment to register functional regions from living participants to cytoarchitectonic areas in ex vivo brains. This novel approach reveals 3 findings. First, there is a consistent relationship between domain-specific regions and cytoarchitectonic areas: each functional region is largely restricted to 1 cytoarchitectonic area. Second, extracting cytoarchitectonic profiles from face- and place-selective regions after back-projecting each region to 20-μm thick histological sections indicates that cytoarchitectonic properties distinguish these regions from each other. Third, some cytoarchitectonic areas contain more than 1 domain-specific region. For example, face-, body-, and character-selective regions are located within the same cytoarchitectonic area. We summarize these findings with a parsimonious hypothesis incorporating how cellular properties may contribute to functional specialization in human VTC. Specifically, we link computational principles to correlated axes of functional and cytoarchitectonic segregation in human VTC, in which parallel processing across domains occurs along a lateral-medial axis while transformations of information within domain occur along an anterior-posterior axis.