Cuproptosis: emerging biomarkers and potential therapeutics in cancers

• Published in: Frontiers in oncology Vol. 13; p. 1288504
• Main Authors: Wang, Min, Zheng, Lianwen, Ma, Shuai, Lin, Ruixin, Li, Jiahui, Yang, Shuli
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 07.11.2023
• Subjects: cancer; cell death; copper; cuproptosis; immunotherapy; metabolism
• ISSN: 2234-943X; 2234-943X
• DOI: 10.3389/fonc.2023.1288504

The sustenance of human life activities depends on copper, which also serves as a crucial factor for vital enzymes. Under typical circumstances, active homeostatic mechanisms keep the intracellular copper ion concentration low. Excess copper ions cause excessive cellular respiration, which causes cytotoxicity and cell death as levels steadily rise above a threshold. It is a novel cell death that depends on mitochondrial respiration, copper ions, and regulation. Cuproptosis is now understood to play a role in several pathogenic processes, including inflammation, oxidative stress, and apoptosis. Copper death is a type of regulatory cell death(RCD).Numerous diseases are correlated with the development of copper homeostasis imbalances. One of the most popular areas of study in the field of cancer is cuproptosis. It has been discovered that cancer angiogenesis, proliferation, growth, and metastasis are all correlated with accumulation of copper ions. Copper ion concentrations can serve as a crucial marker for cancer development. In order to serve as a reference for clinical research on the product, diagnosis, and treatment of cancer, this paper covers the function of copper ion homeostasis imbalance in malignant cancers and related molecular pathways.