Maternal anxiety and depression in pregnancy and DNA methylation of the NR3C1 glucocorticoid receptor gene

To quantify associations of anxiety and depression during pregnancy with differential cord blood DNA methylation of the glucorticoid receptor ( ). Pregnancy anxiety, trait anxiety and depressive symptoms were collected using the Pregnancy Related Anxiety Scale, State-Trait Anxiety Index and Edinburg...

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Bibliographic Details
Published inEpigenomics Vol. 13; no. 21; pp. 1701 - 1709
Main Authors Dereix, Alexandra E, Ledyard, Rachel, Redhunt, Allyson M, Bloomquist, Tessa R, Brennan, Kasey Jm, Baccarelli, Andrea A, Hacker, Michele R, Burris, Heather H
Format Journal Article
LanguageEnglish
Published England Future Medicine Ltd 01.11.2021
Subjects
Anxiety - genetics
CpG Islands
Depression - genetics
DNA Methylation
Female
Humans
Infant
Pregnancy
Receptors, Glucocorticoid - genetics
developmental epigenetics
cord blood
glucocorticoid receptor
pregnancy
DNA methylation
NR3C1
epigenetics
maternal anxiety
maternal depression
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Summary:To quantify associations of anxiety and depression during pregnancy with differential cord blood DNA methylation of the glucorticoid receptor ( ). Pregnancy anxiety, trait anxiety and depressive symptoms were collected using the Pregnancy Related Anxiety Scale, State-Trait Anxiety Index and Edinburgh Postnatal Depression Scale, respectively. methylation was determined at four methylation sites. DNA methylation of CpG1 in the CpG island shore was higher in infants born to women with high pregnancy anxiety (β 2.54, 95% CI: 0.49-4.58) and trait anxiety (β 1.68, 95% CI: 0.14-3.22). No significant association was found between depressive symptoms and methylation. We found that maternal anxiety was associated with increased CpG island shore methylation.
ISSN:1750-1911
1750-192X
DOI:10.2217/epi-2020-0022