Vox Sanguinis International Forum on donor notification and counselling strategies for markers of transfusion‐transmissible infections: summary

• Published in: Vox sanguinis Vol. 112; no. 4; pp. 388 - 396
• Main Authors: Sharma, R. R., Lozano, M., Fearon, M., Bigham, M., Djoudi, R., Gallian, P., Woimant, G., Lee, C., Leung, J. N. S, Tsoi, W. C., Marwaha, N., Sachdev, S., Tadokoro, K., Tani, Y., Matsukura, H., Shantseva, N., Zhiburt, E., Hindawi, S., Chay, J., Huang, T., Teo, D., Moleli, N., Oyonarte, S., Jayasekara, S. B. A., Bokhorst, A., Burg, P., Hewitt, P., Bianco, C., Kessler, D.
• Format: Journal Article
• Language: English
• Published: England S. Karger AG 01.05.2017; Wiley
• Subjects: Alleles; Blood Donors; Blood Group Antigens; Female; Gene Frequency; Genotyping Techniques; Humans; Life Sciences; Male; Mali; Phenotype; Genotyping; Allele frequencies; Africa
• ISSN: 0042-9007; 1423-0410
• DOI: 10.1111/vox.12469

We determined the frequencies of clinically relevant blood group alleles in 300 blood donors from Mali. Multiplex test based on xMAP technology was used to investigate six blood group systems (RH, KEL, MNS, FY, JK, DO, HPA) and complementary analysis were conducted for MNS and RH systems. Polymorphisms that affect the specificity of molecular tests leading to discrepant genotype results are discussed. Antigen expressions were predicted showing that 50% of donors expressed at least one traditional low prevalence antigen, and 11.6% lacked the ability to express at least one high prevalence antigen compatible with Dob-, HPA1a-, S-s-U-, Jsb-, RH:-31 and/or RH:-34 phenotypes.